Inorganic Acids
Aqua Solutions Hydrochloric Acid 0.3 Normal NIST Traceable Solution, 4L
Hydrochloric Acid 0.3 Normal NIST Traceable Solution, 4L
GFS Chemicals Inc ULTMT HYDROCHLORIC ACID 500ML
Hydrochloric Acid, PPT Grade, Veritas Ultimate | 7647-01-0 |
Medchemexpress LLC ARD-69 50mg | 2316837-10-0 | 50 MG
ARD-69 is a PROTAC small-molecule degrader that targets the androgen receptor (AR) and is used in preclinical research to investigate AR signaling and castration-resistant prostate cancer. It recruits the VHL E3 ligase to promote ubiquitination and proteasomal degradation of AR, resulting in decreased AR-driven transcription and inhibited proliferation in AR-positive cell lines.
- Used for preclinical studies of AR degradation and prostate cancer models.
- Potent AR degrader with low-nanomolar cellular activity.
- High chemical purity suitable for biological assays.
- Soluble in DMSO at ≥ 200 mg/mL for in vitro formulation.
- Stable under recommended storage when protected from light.
Electron Microscopy Sciences Hydrochloric Acid 0.05% Solution 500 ML
Used in Papanicolaou Stain for Membrane Filter. Reference: Gill, G.W., ActaCytol., 18:300-311, 1974, Diagnostic Cytology by Membrane Filter, Application Bulletin 100, Gelman Instrument Co., Ann Arbor, Michigan, 1978
Aqua Solutions Hydrochloric Acid (1:1) 50% v/v Solution ASTM D1125-14 (4L)
Hydrochloric Acid (1:1) 50% v/v Solution ASTM D1125-14 (4L)
Medchemexpress LLC ARD-69 | 5MG
ARD-69 is a PROTAC degrader based on the E3 ubiquitin ligase VHL and targeting the androgen receptor which can induce androgen receptor (AR) protein degradation in AR-positive prostate cancer cells ARD-69 inhibits AR-regulated gene expression binds to the AR ligand binding domain at one end and binds to VHL at the other end prompting AR to be recruited to the E3 ubiquitin ligase complex triggering proteasome degradation thereby inhibiting AR signaling pathways and downstream gene expression (such as PSA TMPRSS2) ARD-69 can be used to study the treatment of castration-resistant prostate cancer (mCRPC)[1][2][3] br/ ARD-69 is composed of a target protein ligand (pink part) AR antagonist 14 (HY-172624) a PROTAC linker (black part) tert-Butyl 4-ethynyl-[1 4 -bipiperidine]-1 -carboxylate (HY-W442074) and a VHL-type E3 ubiquitinase ligand (blue part) VH 101 acid (HY-47070) among them the VHL ligand and the linker can form a conjugate VH 101-amide-piperidine-Pip-alkyn